Biosynthesis of Melanotropins and Endorphins by the Lead-haematoxylin Positive Cells in Pars Intermedia of the Cichlid Teleost Sarotherodon Mossambicus
نویسنده
چکیده
1. Biosynthesis in the lead-haematoxylin positive pars intermedia cells of Sarotherodon mossambicus was analysed by SDS and acid-urea electrophoresis and high pressure liquid chromatography. 2. Pulse and pulse-chase experiments revealed that a non-glycosylated 30K-precursor was processed into a number of smaller products. 3. Melanotropic and endorphin-like peptides appeared to be the final products of this precursor-product processing. 4. Our results indicate that the biosynthetic pathways in the lead-haematoxylin positive cells in the teleost pars intermedia are similar to those described for pars intermedia cells in other vertebrate groups.
منابع مشابه
Responses of the PAS-positive pars intermedia cells in the cichlid fish Sarotherodon mossambicus
متن کامل
Isolation of the biosynthetic products of the PAS positive pars intermedia cells in the cichlid teleost Sarotherodon mossambicus.
The pars intermedia of teleosts contains two types of granular cells with the predominant type being similar to the pars intermedia cells in other vertebrate groups and containing peptides derived from the pro-opiomelanocortin precursor molecule. The function and products of the second cell type, the PAS positive cells, are unknown. This study reports on the identification of biosynthetic produ...
متن کاملStructural changes in the pars intermedia of the cichlid teleost Sarotherodon mossambicus as a result of background and adaptation and illumination. III. The role of the pineal organ.
The MSH producing cells in the pars intermedia of Sarotherodon mossambicus have been shown to be involved in background adaptation processes. Reflected light received by the eyes affects the activity of these cells. In the present study the hypothesis has been tested that also the pineal organ, as a second photoreceptor, is involved in regulation of the metabolic activity of the MSH cells. The ...
متن کامل